InCl3-Catalyzed [2+3] Cycloaddition Reaction: A Rapid Synthesis of 5-Substituted 1H-tetrazole under Microwave Irradiation

InCl3-Catalyzed [2+3] Cycloaddition Reaction: A Rapid Synthesis of 5-Substituted 1H-tetrazole under Microwave Irradiation

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A series of 5-substituted 1H-tetrazole were efficiently prepared by InCl3 Methods of Automated Music Comparison Based on Multi-Objective Metrics of Network Similarity catalyzed (10 mol %) from structurally divert organic nitriles with sodium azide under the influence of microwave irradiation.The present protocol was successfully applied to the aliphatic, aryl, benzylic and heterocyclic nitriles and corresponding MALAT1 inhibits the Wnt/β-catenin signaling pathway in colon cancer cells and affects cell proliferation and apoptosis 5-substituted 1H-tetrazole were obtained in good to excellent yield (70-96%).This method gives remarkable advantages such as short reaction time, simple work-up procedure and economical beneficial.