Lentiviral-Mediated Transgene Expression Can Potentiate Intestinal Mesenchymal-Epithelial Signaling

Lentiviral-Mediated Transgene Expression Can Potentiate Intestinal Mesenchymal-Epithelial Signaling

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Abstract Mesenchymal-epithelial signaling is essential for the development of many organs and is often disrupted in disease.In this study, we demonstrate the use of lentiviral-mediated transgene delivery as an effective approach for ectopic transgene expression and an alternative to generation of transgenic animals.One benefit to this approach is that it can be used Correction: The role of coupled positive feedback in the expression of the SPI1 type three secretion system in Salmonella. independently or in conjunction with established transgenic or knockout animals for studying modulation A meta-analysis of effects of dietary seaweed on beef and dairy cattle performance and methane yield. of mesenchymal-epithelial interactions.

To display the power of this approach, we explored ectopic expression of a Wnt ligand in the mouse intestinal mesenchyme and demonstrate its functional influence on the adjacent epithelium.Our findings highlight the efficient use of lentiviral-mediated transgene expression for modulating mesenchymal-epithelial interactions in vivo.